Bioinformatician (Cancer Science Institute, GeDac)

Interested applicants are invited to apply directly at the NUS Career Portal. Please note your application will only be processed if you apply via NUS Career Portal.

NUS Career Portal link: https://careers.nus.edu.sg/job/Bioinformatician-%28Cancer-Science-Institute%2C-GeDac%29/31307-en_GB/

We regret that only shortlisted candidates will be notified.

Job Description

The Cancer Science Institute of Singapore (CSI) is seeking a collaborative and highly skilled Genomic Data Scientist/Bioinformatician to join our Genomics and Data Analytics Core (GeDaC). Our facility is powered by a multi-disciplinary team of cloud engineering experts who are establishing a robust, petabyte-scale infrastructure on AWS for the automated processing and analysis of large-scale cancer genomics datasets.

This role is specifically designed for a scientist who excels at building state-of-the-art bioinformatics workflows for RNA-sequencing analyses. You will leverage our production-grade "AI Factory" to move beyond standard pipelines, exploring the intricate complexities of the transcriptome at a massive scale to advance biological discovery and precision medicine.

Key Responsibilities
Working collaboratively with software engineering experts, principal investigators, and research teams, the successful candidate will:

• Large-Scale Data Operations: Collaborate with a strong engineering team to design and optimize cloud-based components capable of processing and analyzing genomic datasets spanning thousands of patients.
• Intricate RNA Analysis: Lead advanced transcriptomic investigations, with a particular focus on alternative splicing, transcript discovery, RNA editing, and RNA modifications.
• Platform & API Development: Help design biologically-sensible APIs for genome analytics to be utilized by research teams.
• Scientific Collaboration: Provide expert bioinformatics consultation to CSI/NUS investigators, communicating complex results clearly to diverse audiences.
• Strategic Initiatives: Participate in state-of-the-art machine learning, AI, and big data projects driven by institutional and national initiatives.

Requirements

Education & Experience

• Master's or Ph.D. in Genetics, Genomics, Bioinformatics, Computational Biology, or Data Science.
• Proven track record of processing and analyzing high-throughput sequencing data (NGS) at scale, with an emphasis on large-scale RNA-seq or single-cell cohorts.

Technical Skills

• Programming Proficiency: Strong proficiency in Python and/or R.
• Computational Infrastructure: Familiarity with High-Performance Computing (HPC) and/or cloud computing environments (AWS preferred).
  Reproducibility: Understanding of version control systems (Git) and reproducible research practices.

Professional Attributes

• Strong problem-solving abilities and the analytical thinking required to manage multi-thousand sample datasets.
• Commitment to producing high-quality, reproducible work within collaborative, multidisciplinary teams.

Preferred Qualifications

• Specialized RNA Expertise: Demonstrated experience in analyzing splicing, transcript discovery, RNA editing, or RNA modifications.
• Workflow Mastery: Familiarity with workflow management systems such as Nextflow, Snakemake, or WDL.
• Data Management: Understanding of database systems and data management practices.
• Scientific Impact: Authorship on peer-reviewed scientific publications showcasing large-scale genomic analysis.