Research Fellow (Cardiovascular Genomics & Mechanisms)

Interested applicants are invited to apply directly at the NUS Career Portal. Please note your application will only be processed if you apply via NUS Career Portal.

NUS Career Portal link: https://careers.nus.edu.sg/job/Research-Fellow-%28Cardiovascular-Genomics-&-Mechanisms%29/27408-en_GB/?st=9EEFFFE6EA425B032A92FE4EB35073D79073A6C3

We regret that only shortlisted candidates will be notified.

Job Description

We are seeking a highly motivated and independent Research Fellow to join a dynamic research lab focusing on cardiovascular genomics, epigenomics, and molecular mechanisms of heart disease. The successful candidate will leverage cutting-edge genomics (including single-cell multi-omics, scRNA-seq, and spatial transcriptomics) and cellular models (such as human iPSCs) to uncover disease mechanisms, therapeutic targets, and regulatory pathways in cardiovascular biology.

Key Responsibilities

• Lead Research Projects: Design and execute high-impact experimental studies investigating the genetic, transcriptional, and epigenetic drivers of cardiovascular diseases.
• Genomics & Molecular Biology: Perform advanced laboratory techniques, including molecular cloning, next-generation sequencing library preparation, gene editing (CRISPR), and functional assays.
• Bioinformatics & Data Analysis: Analyze complex high-throughput genomics datasets (e.g., scRNA-seq, bulk RNA-seq, ChIP-seq, ATAC-seq, spatial transcriptomics) using robust computational pipelines.
• Cellular Models: Work with human pluripotent stem cell (hPSC)-derived cardiac models or primary tissue models to validate genomic findings functionally.
• Publication & Dissemination: Lead the drafting of manuscripts for peer-reviewed high-impact journals, present research findings at international scientific conferences, and contribute to progress reports.
• Mentorship & Lab Support: Provide guidance, technical training, and mentorship to junior lab members (Research Assistants, postgraduate, and undergraduate students), while maintaining collaborative laboratory operations.

Qualifications

• Education: PhD in Molecular Biology, Genetics, Bioinformatics, Computational Biology, Cardiovascular Science, or a related biomedical discipline.
• Technical Expertise:
• Strong background in molecular biology and functional genomics.
• Demonstrated hands-on experience with genomics assays (NGS workflows, single-cell genomics, epigenomics).
• Familiarity with human stem cell models or cardiovascular disease biology is a strong advantage.
• Computational Skills: Proficiency in bioinformatics programming languages (such as R or Python) for large-scale genomic data analysis.
• Track Record: A strong publication record in peer-reviewed international journals demonstrating scientific productivity and independence.
• Soft Skills: Excellent written and verbal communication skills, strong problem-solving abilities, and a collaborative team player mindset suited for a fast-paced translational research environment.

Only shortlisted candidates will be notified.

Preferred Qualifications

• Knowledge of statistical methods and research design.
• Experience in public health nutrition or community nutrition programs.